Dose-escalated Proton Therapy for Sarcomas of the Skull-base, Spine and Pelvis

Presented by:
Adam L. Holtzman, MD
Assistant Professor, Department of Radiation Oncology
University of Florida
UF Health Proton Therapy Institute

Faculty Disclosure:
Adam L. Holtzman, MD, has disclosed that he has no relevant financial relationships. No one else in a position to control content has any financial relationships to disclose.Conflict of interest information for the CME Advisory Committee members can be found on the following website:

Release Date: February 25, 2021
Expiration Date:  February 25, 2022

Target Audience: This course is intended for an audience of specialty physicians, primary care physicians, physician assistants, nurses, as well as others who treat patients with sarcomas.

Learning Objectives:

As a result of participation in this activity, participants should be able to:

  1. Define proton therapy and describe how proton therapy is different from conventional radiation therapy.
  2. Identify and determine the theoretical advantages to the use of proton therapy in the treatment of sarcomas, specifically chordomas and chondrosarcomas.
  3. Discuss best practices of proton therapy for sarcomas based on current research.

Requirements for successful completion: Certificates are awarded upon successful completion (80% proficiency) of the post-test.

Accreditation: The University of Florida College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit: The University of Florida College of Medicine designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Resource(s) for further study:

  1. Holtzman, A.L., Rotondo, R.L., Rutenberg, M.S. et al. Proton therapy for skull-base chondrosarcoma, a single-institution outcomes study. J Neurooncol 142, 557–563 (2019).
  2. Srivastava A, Vischioni B, Fiore MR, et al. Quality of life in patients with chordomas/chondrosarcomas during treatment with proton beam therapy. J Radiat Res. 2013;54 Suppl 1(Suppl 1):i43-i48. doi:10.1093/jrr/rrt057
  3. Mercado CE, Holtzman AL, Rotondo R, Rutenberg MS, Mendenhall WM. Proton therapy for skull base tumors: A review of clinical outcomes for chordomas and chondrosarcomas. Head Neck. 2019;41(2):536-541. doi:10.1002/hed.25479



For additional information, please contact Christina Mershell at or call 904-831-4034.