Presented by:
Paola Giusti-Rodriguez, PhD
Assistant Professor
Adult Research Division
Department of Psychiatry
Faculty Disclosure:
Dr. Giusti-Rodriguez has disclosed that she has no relevant financial relationships. No one else in a position to control content has any financial relationships to disclose. Conflict of interest information for the CME Advisory Committee members can be found on the following website: https://cme.ufl.edu/disclosure/. All relevant financial relationships have been mitigated.
Release Date: February 16, 2024
Expiration Date: February 15, 2026
Target Audience: All physicians
Learning Objectives:
As a result of participation in this activity, participants should be able to:
- Recognize that psychiatric genomic studies are still suffering from a lack of diversity in the ancestry of populations studied.
- Describe how to calculate a polygenic risk score and why it matters how it is calculated.
- Recognize why it is important to account for ancestry across all phases of a genomics study.
- Summarize what are the top priorities for capacity building in Latin American psychiatric genetics.
Requirements for successful completion: Certificates are awarded upon successful completion (80% proficiency) of the post-test.
Accreditation: The University of Florida College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Credit: The University of Florida College of Medicine designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Resource(s) for further study:
- Peterson RE, et al. Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations. Cell. 2019; 179, 603.
- Martin AR, et al. Clinical use of current polygenic risk scores may exacerbate health disparities. Nat Gen. 2019; 51, 584-591.
- Sullivan PF, et al. Increasing the Clinical Psychiatric Knowledge Base About Pathogenic Copy Number Variation. Am J Psychiatry. 2020; 177(3):204-209. https://doi.org/10.1176/appi.ajp.2019.19040335
- https://www.genome.gov/es/Health/Genomics-and-Medicine/Puntuaciones-de-Riesgo-Polig%C3%A9nico
- Martin AR, et al. Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations. Am J Hum Genet. 2017; 100, 635-649. https://www.cell.com/ajhg/pdf/S0002-9297(17)30107-6.pdf
- Martinez-Magana JJ, et al. Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals. Scientific Reports. 2021; 11, 6771.
- Salum GA, et al. High risk cohort study for psychiatric disorders in childhood: rationale, design, methods, and preliminary results. International Journal of Methods in Psychiatric Research. 2015; 24(1):58-73. https://doi.org/10.1002/mpr.1459
- Contreras J, et al. Quantitative genetic analysis of anxiety trait in bipolar disorder. Journal of Affective Disorders. 2018; 225:395-398. https://doi.org/10.1016/j.jad.2017.08.023
- Atkinson EG, et al. Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power. Nat Gen. 2021; 53, 195-204.
- Murgueito, J., et al. Latin American Genomics Consortium. (2023). Importance of including individuals of Latin American ancestry in genetic studies of feeding and eating disorders. Revista Puertorriqueña de Psicologia, 34(2), 262-283.
If you have any questions please feel free to contact Nancy Boyd at (352) 594-4298 or at nancy.boyd@ufl.edu