Pharmacogenetic Testing and Consultation for Patients

Presented by:
Emily J. Cicali, Pharm.D., BCPS
Associate Professor, College of Pharmacy

Co-Presenters:
Madeline Norris, Pharm.D.
Post-Doctoral Fellow, Clinical Pharmacogenomics Pharmacist

Faculty Disclosure:

Drs. Cicali and Norris have disclosed that they have no relevant financial relationship(s). No one else in a position to control content has any financial relationships to disclose.

Conflict of interest information for the CME Advisory Committee members can be found on the following website: https://cme.ufl.edu/disclosure/. All relevant financial relationships have been mitigated.

Release Date: September 22, 2023
Expiration Date: September 21, 2025

Target Audience: All physicians

Learning Objectives:

As a result of participation in this activity, participants should be able to:

  1. Summarize pharmacogenetic testing & how genetic variations affect the body’s response to certain medications.
  2. Review the gene-drug pairs relevant for Psychiatry patients and relevant evidence.
  3. Discuss how these gene-drug pairs may impact the patient’s response to certain medications & dosages.
  4. Review Psychiatry patient cases.

Requirements for successful completion: Certificates are awarded upon successful completion (80% proficiency) of the post-test.

Accreditation: The University of Florida College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit: The University of Florida College of Medicine designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Resources for further study:

  1. Hicks JK, et al., Clin Pharmacol Ther. 2015;98(2):127-134.
  2. Bousman, Chad A et al., Clin Pharmacol and Ther. 2023; 114(1): 51-68.
  3. Solomon HV, et al., Psychiatry Res. 2019 Jan;271:604-613. PMID: 30554109.
  4. Oslin DW, et al., JAMA. 2022 Jul 12;328(2):151-161.
  5. Smith RL, et al. Br J Clin Pharmacol. 2023;89(7):2246-2253.
  6. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021411s040lbl.pdf
  7. Milosavljevic F, et al. JAMA Psychiatry. 2020; PMID: 33237321.
  8. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021436s038,021713s030,021729s022,021866s023lbl.pdf
  9. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/202971s008lbl.pdf
  10. https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/RISPERDAL-pi.pdf
  11. Zhang L et al. Pharmacotherapy. 2020; PMID: 32519344.
  12. Jukic et al. Lancet Psychiatry. 2019. PMID: 31000417.
  13. Kazeem A et al. Ped Res. 2019. PMID: 30661084.
  14. Lu JY et al. Pharmacogenomics 2020 PMID: 32969762.
  15. https://precisionmedicine.ufhealth.org/phenoconversion-calculator/
  16. Jallaq SA et al. Journal of Child and Adolescent Psychopharmacology. 2020. PMID: 32845723.
  17. Lemke L et al., Frontiers. August 2023. https://www.frontiersin.org/articles/10.3389/fphar.2023.1179364/full

If you have any questions please feel free to contact Nancy Boyd at (352) 594-4298 or at nancy.boyd@ufl.edu