Work Up and Differential Diagnosis of First Episode Seizure Disorder in Pediatric Population with Psychiatric Comorbidity


Presented by:
Ashraf Muzwagi, MD
Sheena John, MD
Young Jo, MD
Child Fellows
Class of 2023

Faculty Disclosure:

Drs. Muzwagi, John, and Jo have disclosed that they have no relevant financial relationships. No one else in a position to control content has any financial relationships to disclose.

Conflict of interest information for the CME Advisory Committee members can be found on the following website: All relevant financial relationships have been mitigated.

Release Date: June 9, 2023
Expiration Date: June 8, 2025

Target Audience: All physicians; LCSW, LMHC, LMFT licensed only in Florida

Learning Objectives:

As a result of participation in this activity, participants should be able to:

  1. Explain the diagnostic approach for first episode seizure disorder in adolescents with psychiatric illness.
  2. Review the pathophysiology of NMDA antibody encephalitis.
  3. Describe the management of psychiatric symptomatology comorbid with seizure disorder.

Requirements for successful completion: Certificates are awarded upon successful completion (80% proficiency) of the post-test.

Accreditation: The University of Florida College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit: The University of Florida College of Medicine designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This program has been approved for 1.0 clinical hours of continuing education for clinical social workers, mental health counselors, and marriage & family therapists by Shands at the University of Florida, Patient and Family Resources,

BAP-7. CEU credits for LCSW, LMHC, LMFT licensed ONLY IN FLORIDA. Certification of completion provided to all participants regardless of state.

Resources for further study:

  1. Dagar, A., & Falcone, T. (2020). Psychiatric Comorbidities in Pediatric Epilepsy. Current psychiatry reports, 22(12), 77.
  2. Kelley BP, Patel SC, Marin HL, Corrigan JJ, Mitsias PD, Griffith B. Autoimmune Encephalitis: Pathophysiology and Imaging Review of an Overlooked Diagnosis. AJNR Am J Neuroradiol. 2017 Jun;38(6):1070-1078. doi: 10.3174/ajnr.A5086. Epub 2017 Feb 9. PMID: 28183838; PMCID: PMC7960083.
  3. Garg D, Mohammad SS, Sharma S. Autoimmune Encephalitis in Children: An Update. Indian Pediatr. 2020 Jul 15;57(7):662-670. PMID: 32727942.
  4. Samanta D, Lui F. Anti-NMDA Receptor Encephalitis. 2022 Dec 22. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 31869136.
  8. Zaborowski MP, Spaczynski M, Nowak-Markwitz E, Michalak S. Paraneoplastic neurological syndromes associated with ovarian tumors. J Cancer Res Clin Oncol. 2015 Jan;141(1):99-108. doi: 10.1007/s00432-014-1745-9. Epub 2014 Jun 26. PMID: 24965744; PMCID: PMC4282879.
  9. Kedare, J. S., & Baliga, S. P. (2022). Management of Psychiatric Disorders in Patients of Epilepsy. Indian journal of psychiatry, 64(Suppl 2), S319–S329.
  10. Mula M. The pharmacological management of psychiatric comorbidities in patients with epilepsy. Pharmacol Res. 2016;107:147–53.
  11. Kanner AM. Management of psychiatric and neurological comorbidities in epilepsy. Nat Rev Neurol. 2016;12:106–16.
  12. Alper K, Schwartz KA, Kolts RL, Khan A. Seizure incidence in psychopharmacological clinical trials: an analysis of Food and Drug Administration (FDA) summary basis of approval reports. Biol Psychiatry. 2007 Aug 15;62(4):345-54. doi: 10.1016/j.biopsych.2006.09.023. Epub 2007 Jan 16. PMID: 17223086.

If you have any questions please feel free to contact Nancy Boyd at (352) 594-4298 or at